primate research suggests that affiliation is a highly complex construct. studies of primate
affiliation demonstrate the need to distinguish between various affiliative behaviors, consider …

Choosing the best genetic strains of mice for developing a new knockout or transgenic
mouse requires extensive knowledge of the endogenous traits of inbred strains. Background …

It is generally acknowledged that humans display highly variable sensitivity to pain,
including variable responses to identical injuries or pathologies. The possible contribution of …

The underlying bases of the considerable interindividual variability in pain-related traits are
starting to be revealed. Although the relative importance of genes versus experience in …

Patients on methadone maintenance therapy are relatively intolerant of pain, a finding
hypothesized to reflect a hyperalgesic state induced by chronic opioid administration. To …

Serotonin (5-hydroxytryptamine, 5-HT) appears to play a role in the pathophysiology of a
range of neuropsychiatric disorders, and serotonergic agents are of central importance in …

Interindividual variability in pain sensitivity and the response to analgesic manipulations
remains a considerable clinical challenge as well as an area of intense scientific …

Providing pain management for known opioid abusers is a challenging clinical task, in part
because little is known about their pain experience and analgesic requirements. This study …

There are differences between human individuals and between mouse strains in levels of μ
opiate receptor (μOR) expression, responses to painful stimuli, and responses to opiate …

Sex and gender deeply affect the subjective effects and pharmaco-toxicological responses
to drugs. Men are more likely than women to use almost all types of illicit drugs and to …