Nanomaterials‐Enabled Physicochemical Antibacterial Therapeutics: Toward the Antibiotic‐Free Disinfections

Z Xing, J Guo, Z Wu, C He, L Wang, M Bai, X Liu, B Zhu… - Small, 2023 - Wiley Online Library
Bacterial infection continues to be an increasing global health problem with the most widely
accepted treatment paradigms restricted to antibiotics. However, the overuse and misuse of …

Re-evaluation of FDA-approved antibiotics with increased diagnostic accuracy for assessment of antimicrobial resistance

DM Heithoff, L Barnes, SP Mahan, JC Fried… - Cell Reports …, 2023 - cell.com
Accurate assessment of antibiotic susceptibility is critical for treatment of antimicrobial
resistant (AMR) infections. Here, we examine whether antimicrobial susceptibility testing in …

An anti-mycobacterial conjugated oligoelectrolyte effective against Mycobacterium abscessus

K Zhang, J Limwongyut, AS Moreland… - Science Translational …, 2024 - science.org
Infections caused by nontuberculous mycobacteria have increased more than 50% in the
past two decades and more than doubled in the elderly population. Mycobacterium …

Cationic Lignin as an Efficient and Biorenewable Antimicrobial Material

K Acurio Cerda, M Kathol, G Purohit… - ACS Sustainable …, 2023 - ACS Publications
In this work, we utilized an inexpensive and naturally abundant polymer lignin and
functionalized it with quaternary ammonium groups to yield a cationic antimicrobial, QAL. As …

Development of cannabidiol derivatives as potent broad-spectrum antibacterial agents with membrane-disruptive mechanism

S Fang, WT Kang, H Li, Q Cai, W Liang, M Zeng… - European Journal of …, 2024 - Elsevier
The emergence of antibiotic resistance has brought a significant burden to public health.
Here, we designed and synthesized a series of cannabidiol derivatives by biomimicking the …

Escherichia coli has an undiscovered ability to inhibit the growth of both Gram-negative and Gram-positive bacteria

E Kastrat, HP Cheng - Scientific Reports, 2024 - nature.com
The ability for bacteria to form boundaries between neighboring colonies as the result of
intra-species inhibition has been described for a limited number of species. Here, we report …

[HTML][HTML] Antimicrobial susceptibility testing to evaluate minimum inhibitory concentration values of clinically relevant antibiotics

L Barnes, DM Heithoff, SP Mahan, JK House… - STAR protocols, 2023 - Elsevier
Antimicrobial susceptibility testing is used to determine the minimum inhibitory concentration
(MIC), the standard measurement of antibiotic activity. Here, we present a protocol for …

The intersection between bacterial metabolism and innate immunity

IC Acosta, F Alonzo 3rd - Journal of Innate Immunity, 2023 - karger.com
Background: The innate immune system is the first line of defense against microbial
pathogens and is essential for maintaining good health. If pathogens breach innate barriers …

Construction of BSA-ZnO&Quercetin based multifunctional bionic self-assembly system and their antibacterial mechanism study

S Hou, Y Hong, J Shang, Y Wang, X Shi, X Liu… - Colloids and Surfaces B …, 2025 - Elsevier
The misuse of antibiotics has led to the growing problem of multidrug-resistant (MDR)
bacteria, and there is still a lack of effective antibacterial agents that can replace antibiotics …

New Strategies for Addressing Antibiotic Resistance Offer Promise, but Time is Running Out

L Mertz - IEEE Pulse, 2023 - ieeexplore.ieee.org
As antibacterial resistance increases—now thought responsible for an estimated 5 million
deaths worldwide each year—scientists are investigating two distinct approaches to …