▪ Abstract Iron-sulfur [Fe-S] clusters are ubiquitous and evolutionary ancient prosthetic
groups that are required to sustain fundamental life processes. Owing to their remarkable …

Iron is vital for almost all living organisms by participating in a wide variety of metabolic
processes, including oxygen transport, DNA synthesis, and electron transport. However, iron …

The heme-regulated kinase HRI is activated under heme/iron deficient conditions; however,
the underlying molecular mechanism is incompletely understood. Here, we show that iron …

The mitochondrion is vital for many metabolic pathways in the cell, contributing all or
important constituent enzymes for diverse functions such as β-oxidation of fatty acids, the …

Work during the past 14 years has shown that mitochondria are the primary site for the
biosynthesis of iron–sulfur (Fe/S) clusters. In fact, it is this process that renders mitochondria …

Mitoferrin 1 and mitoferrin 2 are homologous members of the mitochondrial solute carrier
family. Mitoferrin 1 is required for mitochondrial iron delivery in developing erythrocytes …

Currently 30 human ABC proteins are represented by full sequences in various databases,
and this paper provides a brief overview of these proteins. ABC proteins are composed of …

X-linked sideroblastic anemia and ataxia (XLSA/A) is a recessive disorder characterized by
an infantile to early childhood onset of non-progressive cerebellar ataxia and mild anemia …

Iron has emerged as a significant cause of neurotoxicity in several neurodegenerative
conditions, including Alzheimer's disease (AD), Parkinson's disease (PD), sporadic …

Iron− sulfur (Fe− S) proteins contain prosthetic groups consisting of two or more iron atoms
bridged by sulfur ligands, which facilitate multiple functions, including redox activity …