Postreplicative mismatch repair
J Jiricny - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
The mismatch repair (MMR) system detects non-Watson–Crick base pairs and strand
misalignments arising during DNA replication and mediates their removal by catalyzing …
misalignments arising during DNA replication and mediates their removal by catalyzing …
Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches
F Dietlein, L Thelen, HC Reinhardt - Trends in genetics, 2014 - cell.com
Defects in DNA repair pathways enable cancer cells to accumulate genomic alterations that
contribute to their aggressive phenotype. However, tumors rely on residual DNA repair …
contribute to their aggressive phenotype. However, tumors rely on residual DNA repair …
Induction of autophagy by spermidine promotes longevity
T Eisenberg, H Knauer, A Schauer, S Büttner… - Nature cell …, 2009 - nature.com
Ageing results from complex genetically and epigenetically programmed processes that are
elicited in part by noxious or stressful events that cause programmed cell death. Here, we …
elicited in part by noxious or stressful events that cause programmed cell death. Here, we …
Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair
LS Symington - Microbiology and molecular biology reviews, 2002 - Am Soc Microbiol
The process of homologous recombination is a major DNA repair pathway that operates on
DNA double-strand breaks, and possibly other kinds of DNA lesions, to promote error-free …
DNA double-strand breaks, and possibly other kinds of DNA lesions, to promote error-free …
DNA mismatch repair and genetic instability
BD Harfe, S Jinks-Robertson - Annual review of genetics, 2000 - annualreviews.org
▪ Abstract Mismatch repair (MMR) systems play a central role in promoting genetic stability
by repairing DNA replication errors, inhibiting recombination between non-identical DNA …
by repairing DNA replication errors, inhibiting recombination between non-identical DNA …
[HTML][HTML] Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break
R Shroff, A Arbel-Eden, D Pilch, G Ira, WM Bonner… - Current Biology, 2004 - cell.com
Background: In response to DNA double-strand breaks (DSBs), eukaryotic cells rapidly
phosphorylate histone H2A isoform H2AX at a C-terminal serine (to form γ-H2AX) and …
phosphorylate histone H2A isoform H2AX at a C-terminal serine (to form γ-H2AX) and …
DNA mismatch repair: molecular mechanisms and biological function
MJ Schofield, P Hsieh - Annual Reviews in Microbiology, 2003 - annualreviews.org
▪ Abstract DNA mismatch repair (MMR) guards the integrity of the genome in virtually all
cells. It contributes about 1000-fold to the overall fidelity of replication and targets mispaired …
cells. It contributes about 1000-fold to the overall fidelity of replication and targets mispaired …
In vivo roles of Rad52, Rad54, and Rad55 proteins in Rad51-mediated recombination
N Sugawara, X Wang, JE Haber - Molecular cell, 2003 - cell.com
Repairing a double-strand break by homologous recombination requires binding of the
strand exchange protein Rad51p to ssDNA, followed by synapsis with a homologous donor …
strand exchange protein Rad51p to ssDNA, followed by synapsis with a homologous donor …
Base triplet stepping by the Rad51/RecA family of recombinases
DNA strand exchange plays a central role in genetic recombination across all kingdoms of
life, but the physical basis for these reactions remains poorly defined. Using single-molecule …
life, but the physical basis for these reactions remains poorly defined. Using single-molecule …
Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates
DNA mismatch repair (MMR) increases replication fidelity by eliminating mispaired bases
resulting from replication errors. In Saccharomyces cerevisiae, mispairs are primarily …
resulting from replication errors. In Saccharomyces cerevisiae, mispairs are primarily …