Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling
metabolites whose versatile modes of action are being increasingly appreciated. These …

Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of
inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules …

Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient
with its negative bioenergetic impact on reactions liberating phosphate. Phosphate …

Land plants have evolved sophisticated sensing mechanisms and signaling pathways to
adapt to phosphate-limited environments. While molecular players contributing to these …

Inositol pyrophosphates (PP-InsPs) are nutrient messengers whose cellular levels are
precisely regulated. Diphosphoinositol pentakisphosphate kinases (PPIP5Ks) generate the …

The inositol pyrophosphates (PP-IPs) are specialized members of the wider inositol
phosphate signaling family that possess functionally significant diphosphate groups. The PP …

Water-soluble myo-inositol phosphates have long been characterized as second
messengers. The signaling properties of these compounds are determined by the number …

Inositol phosphates (InsPs) are ubiquitous in all eukaryotes. However, since there are 63
possible different phosphate ester isomers, the analysis of InsPs is challenging. In particular …

Inositol pyrophosphates (PP-InsPs) are energetic signaling molecules with important
functions in mammals. As their biosynthesis depends on ATP concentration, PP-InsPs are …

Photosynthesis plays a vital role in acclimating to and mitigating climate change, providing
food and energy security for a population that is constantly growing, and achieving an …