Dysregulated pH is a common characteristic of cancer cells, as they have an increased
intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells …

Lang, Florian, Gillian L. Busch, Markus Ritter, Harald Völkl, Siegfried Waldegger, Erich
Gulbins, and Dieter Häussinger. Functional Significance of Cell Volume Regulatory …

Alterations in tumour metabolism and acid/base regulation result in the formation of a hostile
environment, which fosters tumour growth and metastasis. Acid/base homoeostasis in …

The cellular hydration state is dynamic and changes within minutes under the influence of
aniso-osmolarity, hormones, nutrients and oxidative stress. This occurs despite the activity of …

Cellular hydration can change within minutes under the influence of hormones, nutrients,
and oxidative stress. Such short-term modulation of cell volume within a narrow range acts …

Mammalian cells utilize a wide variety of cell volume regulatory mechanisms. For rapid
adjustment of cell volume cells release or accumulate ions through respective channels and …

Cancer cells and tissues, regardless of their origin and genetic background, have an
aberrant regulation of hydrogen ion dynamics leading to a reversal of the intracellular to …

Research over the past 25 years has identified specific ion transporters and channels that
are activated by acute changes in cell volume and that serve to restore steady-state volume …

The change of a normal, healthy cell to a transformed cell is the first step in the evolutionary
arc of a cancer. While the role of oncogenes in this 'passage'is well known, the role of ion …

Cancer cells display alterations in many cellular processes. One core hallmark of cancer is
the Warburg effect which is a glycolytic reprogramming that allows cells to survive and …