The limitations of genome-wide association (GWA) studies that focus on the phenotypic
influence of common genetic variants have motivated human geneticists to consider the …

There has been increasing interest in rare variants and their association with disease, and
several rare variant–disease associations have already been detected. The usual …

Spatial transcriptomic studies are becoming increasingly common and large, posing
important statistical and computational challenges for many analytic tasks. Here, we present …

We propose in this paper a unified approach for testing the association between rare
variants and phenotypes in sequencing association studies. This approach maximizes …

GWAS have emerged as popular tools for identifying genetic variants that are associated
with disease risk. Standard analysis of a case-control GWAS involves assessing the …

Biological and empirical evidence suggests that rare variants account for a large proportion
of the genetic contributions to complex human diseases. Recent technological advances in …

In anticipation of the availability of next‐generation sequencing data, there is increasing
interest in investigating association between complex traits and rare variants (RVs). In …

Prediction of genetic values has been a focus of applied quantitative genetics since the
beginning of the 20th century, with renewed interest following the advent of the era of whole …

Association mapping of complex traits typically employs tagSNP genotype data to identify a
trait locus within a region of interest. However, considerable debate exists regarding the …

Several two-sample tests for high-dimensional data have been proposed recently, but they
are powerful only against certain alternative hypotheses. In practice, since the true …