The existence of a selective blood-brain barrier (BBB) and neurovascular coupling are two
unique central nervous system vasculature features that result in an intimate relationship …

The blood-brain-barrier (BBB) has a major function in maintaining brain homeostasis by
regulating the entry of molecules from the blood to the brain. Key players in BBB function are …

Simple Summary Overexpression of ABCB1 has been identified in a wide range of multidrug-
resistant cancers. ABCB1 can become upregulated in many ways, and understanding these …

Calcium is a ubiquitous second messenger that is indispensable in regulating
neurotransmission and memory formation. A precise intracellular calcium level is achieved …

Although Alzheimer's disease (AD) is traditionally viewed as a central nervous system
disorder driven by the cerebral accumulation of toxic beta-amyloid (Aβ) peptide, new …

Background Failure to clear Aβ from the brain is partly responsible for Aβ brain accumulation
in Alzheimer's disease (AD). A critical protein for clearing Aβ across the blood-brain barrier …

Antibiotic resistance is a global issue that threatens our progress in healthcare and life
expectancy. In recent years, antimicrobial peptides (AMPs) have been considered as …

Alzheimer's disease (AD) is the most common form of neurodegenerative disease. The
predominant characteristics of AD are the accumulation of amyloid-β (Aβ) and …

Alzheimer's disease (AD) is a global health problem, with incidence and prevalence
considered to increase during the next decades. However, no currently available effective …

Over the last decade, significant progress been made in elucidating the role of membrane
transporters in altering drug disposition, with important toxicological consequences due to …