Current delivery strategies for cancer therapeutics commonly cause significant systemic side
effects due to required high doses of therapeutic, inefficient cellular uptake of drug, and poor …

Numerous endosomolytic agents have been developed to facilitate nanoparticle escape
from the endosome and prevent destruction in the lysosome. Many endosomolytic agents …

Highlights•KALA-LMWP-NLS chimeric peptide (KLN) was designed and expressed in E. coli
Bl21.•KLN/pDNA/Aptamer nanoparticles were synthesized using electrostatic self …

Small interfering RNA (siRNA) can be exploited to silence specific genes associated with
cancer development, and successful siRNA therapy is highly dependent on the efficiency of …

Targeted tumour therapy has proved to be an efficient alternative to overcome the limitations
of conventional chemotherapy. Among several receptors upregulated in cancer cells, the …

The development of polymer-based nanoparticulate delivery systems for siRNA is important
for the clinical success of gene therapy. However, there are some major drawbacks that …

Purpose Exendin, an analogue of the glucagon-like peptide 1 (GLP1), is an excellent tracer
for molecular imaging of pancreatic beta cells and beta cell-derived tumours. The commonly …

Uterine leiomyoma (UL) is one of the most common benign tumors in women that often
leads to many reproductive complications. Suicide genetherapy was suggested as a …

Gene therapy is the most effective treatment option for diseases, but its effectiveness is
affected by the choice and design of gene carriers. The genes themselves have to pass …

Targeted tumour therapy has proved to be an efficient alternative to overcome the limitations
of conventional chemotherapy. The upregulation of the bombesin receptor 2 (BB2) in …