Congenital lung malformations

F Pederiva, SS Rothenberg, N Hall… - Nature Reviews …, 2023 - nature.com
Congenital lung malformations (CLMs) are rare developmental anomalies of the lung,
including congenital pulmonary airway malformations (CPAM), bronchopulmonary …

Building and regenerating the lung cell by cell

JA Whitsett, TV Kalin, Y Xu… - Physiological …, 2019 - journals.physiology.org
The unique architecture of the mammalian lung is required for adaptation to air breathing at
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …

Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus

JA Zepp, MP Morley, C Loebel, MM Kremp… - Science, 2021 - science.org
INTRODUCTION The alveolar region of the lung develops in a period that spans the late
embryonic and early postnatal stages of life. An intricate series of events—including cellular …

Congenital lung malformations: unresolved issues and unanswered questions

F Annunziata, A Bush, F Borgia, F Raimondi… - Frontiers in …, 2019 - frontiersin.org
Advances in prenatal and postnatal diagnosis, perioperative management, and
postoperative care have dramatically increased the number of scientific reports on …

Single-cell transcriptomic profiling of pluripotent stem cell-derived SCGB3A2+ airway epithelium

KB McCauley, KD Alysandratos, A Jacob, F Hawkins… - Stem cell reports, 2018 - cell.com
Lung epithelial lineages have been difficult to maintain in pure form in vitro, and lineage-
specific reporters have proven invaluable for monitoring their emergence from cultured …

Developmental pathways underlying lung development and congenital lung disorders

I Caldeira, H Fernandes-Silva, D Machado-Costa… - Cells, 2021 - mdpi.com
Lung organogenesis is a highly coordinated process governed by a network of conserved
signaling pathways that ultimately control patterning, growth, and differentiation. This …

Defining the spatial landscape of KRAS mutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features

ND Nelson, F Xu, P Chandrasekaran, LA Litzky… - Modern …, 2022 - nature.com
The potential pathogenetic mechanisms underlying the varied morphology of congenital
pulmonary airway malformations (CPAMs) have not been molecularly determined, but a …

Congenital lung malformations: dysregulated lung developmental processes and altered signaling pathways

F Doktor, L Antounians, M Lacher, A Zani - Seminars in Pediatric Surgery, 2022 - Elsevier
Congenital lung malformations comprise a diverse group of anomalies including congenital
pulmonary airway malformation (CPAM, previously known as congenital cystic adenomatoid …

Development of a multi-institutional registry for children with operative congenital lung malformations

SM Kunisaki, JM Saito, ME Fallat, SDS Peter… - Journal of pediatric …, 2020 - Elsevier
Introduction The purpose of this study was to develop a multi-institutional registry to
characterize the demographics, management, and outcomes of a contemporary cohort of …

Congenital lung malformations

J Palla, MM Sockrider - Pediatric annals, 2019 - journals.healio.com
Congenital lung malformations (CLM) comprise a spectrum of anatomical anomalies of the
lungs and respiratory tree. The prenatal growth pattern of CLMs is unpredictable with larger …