Emotion, memories and behaviour emerge from the coordinated activities of regions
connected by the limbic system. Here, we propose an update of the limbic model based on …

Functional and structural connectivity measures, as assessed by means of functional and
diffusion MRI, are emerging as potential intermediate biomarkers for Alzheimer disease (AD) …

Few themes have been more central to neurological models of aphasia than the
disconnection paradigm and the role of the arcuate fasciculus. Introduced by luminaries of …

Background Behavioral variant frontotemporal dementia (bvFTD) strikes hardest at the
frontal lobes, but the sites of earliest injury remain unclear. Objective To determine atrophy …

Primary progressive aphasia is a clinical syndrome that encompasses three major
phenotypes: non-fluent/agrammatic, semantic and logopenic. These clinical entities have …

Diffusion-based tractography enables the graphical reconstruction of the white matter
pathways in the brain and spinal cord of living humans. This technique has many potential …

Frontotemporal dementia (FTD) and Alzheimer's disease are sometimes difficult to
differentiate clinically because of overlapping symptoms. Using diffusion tensor imaging …

Cognitive deficits in semantic dementia have been attributed to anterior temporal lobe grey
matter damage; however, key aspects of the syndrome could be due to altered anatomical …

The primary progressive aphasias (PPA) are paradigmatic disorders of language network
breakdown associated with focal degeneration of the left cerebral hemisphere. Here we …

Objective: To use diffusion tensor imaging (DTI) to assess gray matter and white matter tract
diffusion in behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SMD) …