Dysfunction of cerebrovascular endothelial cells: prelude to vascular dementia

F Wang, Y Cao, L Ma, H Pei, WD Rausch… - Frontiers in aging …, 2018 - frontiersin.org
Vascular dementia (VaD) is the second most common type of dementia after Alzheimer's
disease (AD), characterized by progressive cognitive impairment, memory loss, and thinking …

Calcium/calmodulin–dependent protein kinase II in cerebrovascular diseases

X Zhang, J Connelly, ES Levitan, D Sun… - Translational Stroke …, 2021 - Springer
Cerebrovascular disease is the most common life-threatening and debilitating condition that
often leads to stroke. The multifunctional calcium/calmodulin-dependent protein kinase II …

Maternal high-fat diet results in cognitive impairment and hippocampal gene expression changes in rat offspring

ZA Cordner, SG Khambadkone, GJ Boersma… - Experimental …, 2019 - Elsevier
Consumption of a high-fat diet has long been known to increase risk for obesity, diabetes,
and the metabolic syndrome. Further evidence strongly suggests that these same metabolic …

[HTML][HTML] Pharmacological treatment of vascular dementia: a molecular mechanism perspective

H Kuang, ZF Zhou, YG Zhu, ZK Wan, MW Yang… - Aging and …, 2021 - ncbi.nlm.nih.gov
Vascular dementia (VaD) is a neurodegenerative disease, with cognitive dysfunction
attributable to cerebrovascular factors. At present, it is the second most frequently occurring …

[HTML][HTML] Rehmannioside A attenuates cognitive deficits in rats with vascular dementia (VD) through suppressing oxidative stress, inflammation and apoptosis

M Sun, X Shen, Y Ma - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Vascular dementia (VD) is a degenerative cerebrovascular disorder, leading to progressive
decline of cognitive abilities and memory. Rehmannioside A (ReA) is isolated from …

Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease

R Tarawneh, RS Kasper, J Sanford… - Annals of clinical …, 2022 - Wiley Online Library
Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease
(AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a …

Sirtuin 1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons

Z Zhang, X Ding, Z Zhou, Z Qiu, N Shi, S Zhou, L Du… - Pain, 2019 - journals.lww.com
Accumulating evidence has demonstrated that the enhanced synaptic plasticity of
nociceptive interneurons in the spinal dorsal horn is the basis of central sensitization in …

Independent component analysis based gene co-expression network inference (ICAnet) to decipher functional modules for better single-cell clustering and batch …

W Wang, H Tan, M Sun, Y Han, W Chen… - Nucleic acids …, 2021 - academic.oup.com
With the tremendous increase of publicly available single-cell RNA-sequencing (scRNA-
seq) datasets, bioinformatics methods based on gene co-expression network are becoming …

Low-Intensity Focused Ultrasound Stimulation Ameliorates Working Memory Dysfunctions in Vascular Dementia Rats via Improving Neuronal Environment

F Wang, Q Wang, L Wang, J Ren, X Song… - Frontiers in aging …, 2022 - frontiersin.org
Working memory impairment is one of the remarkable cognitive dysfunctions induced by
vascular dementia (VD), and it is necessary to explore an effective treatment. Recently, low …

[HTML][HTML] Neurogranin as an important regulator in swimming training to improve the spatial memory dysfunction of mice with chronic cerebral hypoperfusion

H Lin, J Zhang, Y Dai, H Liu, X He, L Chen… - Journal of Sport and …, 2023 - Elsevier
Background Vascular cognitive impairment caused by chronic cerebral hypoperfusion
(CCH) has become a hot issue worldwide. Aerobic exercise positively contributes to the …