P2X receptors are membrane ion channels that open in response to the binding of
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …

Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

Significant progress in understanding the pharmacological characteristics and physiological
importance of homomeric and heteromeric P2X channels has been achieved in recent …

It is now widely recognised that extracellular nucleotides, signalling via purinergic receptors,
participate in numerous biological processes in most tissues. It has become evident that …

P2X receptors are a family of trimeric ion channels that are gated by extracellular adenosine
5′-triphosphate (ATP). These receptors have long been a subject of intense research …

We constructed a full-length human P2X5 purinoceptor cDNA by incorporating a sequence
corresponding to exon 10, which is missing in cDNAs cloned previously from human tissues …

Nucleotides are of crucial importance as carriers of energy in all organisms. However, the
concept that in addition to their intracellular roles, nucleotides act as extracellular ligands …

The P2X receptor is the baby brother of the ligand-gated ion channel super-family. An
understanding of its role in human physiology is still developing, and no one truly knows …

Transcripts and/or proteins of P2X receptor (P2XR) subunits have been found in virtually all
mammalian tissues. Generally more than one of the seven known P2X subunits have been …