Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino
acid is:(i) A main precursor of extracellular collagens (the most abundant human proteins) …

Collagen is one of the most abundant proteins in animals and a major component of the
extracellular matrix (ECM) in tissues. Besides playing a role as a structural building block of …

Cancer cells show a formidable capacity to survive under stringent conditions, to elude
mechanisms of control, such as apoptosis, and to resist therapy. Cancer cells reprogram …

Cancer cells often change their metabolism to support uncontrolled proliferation. Proline is
the only proteogenic secondary amino acid that is abundant in the body. Recent studies …

Abstract Purpose of Review Osteoblasts are responsible for bone matrix production during
bone development and homeostasis. Much is known about the transcriptional regulation …

Collagen is the main component of the extracellular matrix. Hydroxylation of proline residues
on collagen, catalyzed by collagen prolyl 4-hydroxylase (C-P4H), is essential for the stability …

The role of vitamin C in the treatment of cancer has been subject to controversy for decades.
Within the past 10 years, mechanistic insight into the importance of vitamin C in epigenetic …

Floating spheroidal aggregates of mouse embryonic stem cells can develop into
polarized/elongated organoids, namely gastruloids. We set up a high-performing assay to …

As per a report of the world health organization, an estimated 9.6 million people died due to
cancer in 2018, globally. Most of the cancer death attributed to the lack of early detection …