The oxidative and nitrosative responses generated by animals and plants are important
defenses against infection and establishment of pathogenic microorganisms such as …

Thiol-based redox switches evolved as efficient post-translational regulatory mechanisms
that enable individual proteins to rapidly respond to sudden environmental changes. While …

Protein oligomerization is central to biological function and regulation, yet its experimental
quantification and measurement of dynamic transitions in solution remain challenging. Here …

Axenic culture of Leishmania is generally performed in rich, serum-supplemented media
which sustain robust growth over multiple passages. The use of such undefined media …

Typical 2-Cys peroxiredoxins (2-Cys Prx) are ubiquitous Cys-based peroxidases, which are
stable as decamers in the reduced state, and may dissociate into dimers upon disulfide …

Crystallins comprise the protein-rich tissue of the eye lens. Of the three most common
vertebrate subtypes, β-crystallins exhibit the widest degree of polydispersity due to their …

Peroxiredoxins (Prxs) have been shown to be important enzymes for trypanosomatids,
counteracting oxidative stress and promoting cell infection and intracellular survival. In this …

Trypanosoma cruzi is the causative agent of Chagas disease which is currently treated by
nifurtimox (NFX) and benznidazole (BZ). Nevertheless, the mechanism of action of NFX is …

The three families of thiol-or selenol-based peroxidases (peroxiredoxins, Prx; glutathione
peroxidases, GPx; and organic hydroperoxide resistance protein/osmotically inducible …

Em infecções causadas por fungos patogênicos, o estresse oxidativo/nitrosativo promovido
por células de defesa do hospedeiro e/ou pela ação de fungicidas, é utilizado para controlar …