Matrine is an alkaloid extracted from traditional Chinese herbs including Sophora
flavescentis, Sophora alopecuroides, Sophora root, etc. It has the dual advantages of …

Cardiac arrhythmias are a major cause of morbidity and mortality. In younger patients, the
majority of sudden cardiac deaths have an underlying Mendelian genetic cause. Over the …

Cellular electrophysiology experiments, important for understanding cardiac arrhythmia
mechanisms, are usually performed with channels expressed in non myocytes, or with non …

Human-induced pluripotent stem cells (hiPSCs) can differentiate into functional
cardiomyocytes; however, the electrophysiological properties of hiPSC-derived …

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are widely used
in studying basic mechanisms of cardiac arrhythmias that are caused by ion …

Explanations for arrhythmia mechanisms at the cellular level are usually based on
experiments in nonhuman myocytes. However, subtle electrophysiological differences …

During the last two decades, significant progress has been made in the identification of
genetic defects underlying inherited arrhythmia syndromes, which has provided some …

The ability of human pluripotent stem cells (hPSCs) to differentiate into any cell type of the
three germ layers makes them a very promising cell source for multiple purposes, including …

TASK-1, a member of the recently identified K2P channel family, is mainly expressed in the
heart and the nervous system. TASK-1 is regulated by several physiological and …

Automated planar patch clamp systems are widely used in drug evaluation studies because
of their ability to provide accurate, reliable, and reproducible data in a high-throughput …