The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

Aortic valve stenosis due to calcification of the valve leaflets is the most common valve
disease in the developed world. It is the third leading cause of cardiovascular disease. 1 …

Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence
indicates that the mitral valve is not a passive structure, but—even in adult life—remains …

Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …

Ferroptosis is a form of regulated cell death that involves metabolic dysfunction resulting
from iron-dependent excessive lipid peroxidation. Elevated plasma levels of free fatty acids …

The cardiac extracellular matrix (ECM) is a complex architectural network consisting of
structural and nonstructural proteins, creating strength and plasticity. The nonstructural …

Periostin, also termed osteoblast-specific factor 2, is a matricellular protein with known
functions in osteology, tissue repair, oncology, cardiovascular and respiratory systems, and …

The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

The earliest description of calcific aortic stenosis is attributed to the French physician Lazare
Rivière who, in 1663, reported the necropsy findings from a patient with palpitations …

Calcific aortic valve stenosis (CAVS) is a major health problem facing aging societies. The
identification of osteoblast-like and osteoclast-like cells in human tissue has led to a major …