Neurofibromin is a large and multifunctional protein encoded by the tumor suppressor gene
NF1, mutations of which cause the tumor predisposition syndrome neurofibromatosis type 1 …

Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and
astrocytes constitute macroglia. This review deals with the recent progress related to the …

Astrocytes can be generated from various tissue sources including human pluripotent stem
cells (PSC). In this manuscript, we describe a chemically defined xeno-free medium culture …

Summary Historically, neurofibromatosis 1 (NF1) has been inextricably linked with
neurofibromatosis 2 (NF2). Both are inherited autosomal-dominant neurocutaneous …

Neurofibromatosis type 1 (NF1), also called von Recklinghausen disease or peripheral
neurofibromatosis, is a common autosomal dominant disorder characterised by multiple …

Abstract Neurofibromatosis type 1 (NF1) is a relatively common tumour predisposition
syndrome related to germline aberrations of NF1, a tumour suppressor gene. The gene …

Von Recklinghausen neurofibromatosis, or type 1 neurofibromatosis (NF1), is a common
autosomal dominant disorder characterized by abnormalities in multiple tissues derived from …

Multiple sclerosis (MS) is the most frequent, demyelinating disease of the central nervous
system (CNS) in Northern Europeans and North Americans. Despite intensive research its …

Individuals with neurofibromatosis type 1 (NF1) have an increased risk of developing benign
and malignant tumours. The NF1 gene is thought to be a tumour suppressor gene, yet no …

Neurofibromin is a cytoplasmic protein that is predominantly expressed in neurons,
Schwann cells, oligodendrocytes, astrocytes and leukocytes. It is encoded by the gene NF1 …