Pathophysiology of chemotherapy-induced peripheral neuropathy

H Starobova, I Vetter - Frontiers in molecular neuroscience, 2017 - frontiersin.org
Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several
antineoplastics. It can lead to detrimental dose reductions and discontinuation of treatment …

Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice …

DL Hershman, C Lacchetti, RH Dworkin… - Journal of clinical …, 2014 - ascopubs.org
Purpose To provide evidence-based guidance on the optimum prevention and treatment
approaches in the management of chemotherapy-induced peripheral neuropathies (CIPN) …

Pathomechanisms of paclitaxel-induced peripheral neuropathy

I Klein, HC Lehmann - Toxics, 2021 - mdpi.com
Peripheral neuropathy is one of the most common side effects of chemotherapy, affecting up
to 60% of all cancer patients receiving chemotherapy. Moreover, paclitaxel induces …

Chemotherapy‐induced peripheral neurotoxicity: a critical analysis

SB Park, D Goldstein, AV Krishnan… - CA: a cancer journal …, 2013 - Wiley Online Library
With a 3‐fold increase in the number of cancer survivors noted since the 1970s, there are
now over 28 million cancer survivors worldwide. Accordingly, there is a heightened …

Long-term effects, pathophysiological mechanisms, and risk factors of chemotherapy-induced peripheral neuropathies: a comprehensive literature review

N Kerckhove, A Collin, S Condé, C Chaleteix… - Frontiers in …, 2017 - frontiersin.org
Neurotoxic anticancer drugs, such as platinum-based anticancer drugs, taxanes, vinca
alkaloids, and proteasome/angiogenesis inhibitors are responsible for chemotherapy …

Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: prevalence, risk factors, and fall risk

T Bao, C Basal, C Seluzicki, SQ Li, AD Seidman… - Breast cancer research …, 2016 - Springer
Chemotherapy-induced peripheral neuropathy (CIPN) is a common toxicity associated with
chemotherapy, but researchers rarely study its risk factors, fall risk, and prevalence in long …

Acupuncture for chemotherapy‐induced peripheral neuropathy in breast cancer survivors: A randomized controlled pilot trial

W Lu, A Giobbie‐Hurder, RA Freedman, IH Shin… - The …, 2020 - academic.oup.com
Background Chemotherapy‐induced peripheral neuropathy (CIPN) is one of the most
debilitating long‐term side effects in breast cancer survivors. We conducted a randomized …

Taxane‐induced neurotoxicity: Pathophysiology and therapeutic perspectives

R da Costa, GF Passos, NLM Quintão… - British journal of …, 2020 - Wiley Online Library
Taxane‐derived drugs are antineoplastic agents used for the treatment of highly common
malignancies. Paclitaxel and docetaxel are the most commonly used taxanes; however …

[HTML][HTML] Persistence of docetaxel-induced neuropathy and impact on quality of life among breast cancer survivors

L Eckhoff, AS Knoop, MB Jensen, M Ewertz - European Journal of Cancer, 2015 - Elsevier
Background This study evaluates persistence and severity of docetaxel-induced neuropathy
(peripheral neuropathy (PN)) and impact on health related quality of life in survivors from …

Efficacy of metformin in prevention of paclitaxel-induced peripheral neuropathy in breast cancer patients: A randomized controlled trial

HM Bakry, NO Mansour, TR ElKhodary… - Frontiers in …, 2023 - frontiersin.org
Background: Paclitaxel-induced peripheral neuropathy (PN) is a serious clinical problem
with no approved drug for prevention. This study aimed to examine the neuroprotective …