Cellular memory is provided by two counteracting groups of chromatin proteins termed
Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate …

“Germ granules” are cytoplasmic, nonmembrane-bound organelles unique to germline.
Germ granules share components with the P bodies and stress granules of somatic cells, but …

The DNA-repair capacity in somatic cells is limited compared with that in germ cells. It has
remained unknown whether not only lesion-type-specific, but overall repair capacities could …

Chromatin remodellers are specialized multi-protein machines that enable access to
nucleosomal DNA by altering the structure, composition and positioning of nucleosomes. All …

Proteins that are related to the retinoblastoma tumour suppressor pRB and the E2F
transcription factor are conserved in many species of plants and animals. The mammalian …

Signals generated in response to extracellular stimuli at the plasma membrane are
transmitted through cytoplasmic transduction cascades to the nucleus. We report the …

Oocytes and sperm are some of the most differentiated cells in our bodies, yet they generate
all cell types after fertilization. Accumulating evidence suggests that this extraordinary …

Pluripotent cells possess the ability to differentiate into any cell type. Commitment to
differentiate into specific lineages requires strict control of gene expression to coordinate the …

Epigenetic information undergoes extensive reprogramming in the germline between
generations. This reprogramming may be essential to establish a developmental ground …

Complex biological processes such as embryogenesis require precise coordination of cell
differentiation programs across both space and time. Using protein-fusion fluorescent …