Antibiotic-resistant infections are an urgent problem in clinical settings because they sharply
increase mortality risk in critically ill patients. The horizontal spread of antibiotic resistance …

The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat
to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant …

Background Gaps in the diagnostic capacity and heterogeneity of national surveillance and
reporting standards in Europe make it difficult to contain carbapenemase-producing …

Surveillance studies have shown that OXA-48-like carbapenemases are the most common
carbapenemases in Enterobacterales in certain regions of the world and are being …

Carbapenems, our one-time silver bullet for multidrug resistant bacterial infections, are now
threatened by widespread dissemination of carbapenem-resistant Enterobacteriaceae …

The management of infections due to Klebsiella pneumoniae has been complicated by the
emergence of antimicrobial resistance, especially to carbapenems. Resistance to …

In 2012, the European Centre for Disease Prevention and Control (ECDC) launched the
'European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE)'project to …

The emergence of carbapenem-resistant enterobacterial species poses a serious threat to
public health worldwide. OXA-48-type carbapenem-hydrolyzing class D β-lactamases are …

Carbapenemase-producing Enterobacteriaceae (CPE) contribute significantly to the global
public health threat of antimicrobial resistance. OXA-48 and its variants are unique …

Escherichia coli is the most common Gram-negative bacterial pathogen, presenting both a
clinical and an epidemiological challenge. In the last decade, several successful multidrug …