Designing spatial and temporal control of vaccine responses

GA Roth, VCTM Picece, BS Ou, W Luo… - Nature Reviews …, 2022 - nature.com
Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …

Metal-based nano-vaccines for cancer immunotherapy

J Li, H Ren, Y Zhang - Coordination Chemistry Reviews, 2022 - Elsevier
Cancer vaccination is an effective way to prevent or cure cancers by inducing strong cellular
and humoral immunity with the aid of delivery carriers or adjuvants. Increasing new delivery …

Autoimmune inflammatory rheumatic diseases post-COVID‐19 vaccination

A Safary, K Esalatmanesh, AT Eftekharsadat… - International …, 2022 - Elsevier
Vaccination against COVID-19 is one of the critical tools to provide herd immunity, reduce
mortality, and control the pandemic worldwide. Despite the safety of vaccination against …

Involvement of inflammation and its resolution in disease and therapeutics

S Alfaro, V Acuña, R Ceriani, MF Cavieres… - International Journal of …, 2022 - mdpi.com
Inflammation plays a critical role in the response to and survival from injuries and/or
infections. It occurs in two phases: initiation and resolution; however, when these events do …

[HTML][HTML] Vaccine-and natural infection-induced mechanisms that could modulate vaccine safety

RN Kostoff, D Kanduc, AL Porter, Y Shoenfeld… - Toxicology reports, 2020 - Elsevier
A degraded/dysfunctional immune system appears to be the main determinant of
serious/fatal reaction to viral infection (for COVID-19, SARS, and influenza alike). There are …

[HTML][HTML] Efficacy and safety of immunological adjuvants. Where is the cut-off?

A Batista-Duharte, DT Martínez, IZ Carlos - Biomedicine & …, 2018 - Elsevier
Research over the past several decades has provided insight into the mode of action of
adjuvants. However, the main focus of attention has been the efficacy in the induction of …

Choice and design of adjuvants for parenteral and mucosal vaccines

HFJ Savelkoul, VA Ferro, MM Strioga, VEJC Schijns - Vaccines, 2015 - mdpi.com
The existence of pathogens that escape recognition by specific vaccines, the need to
improve existing vaccines and the increased availability of therapeutic (non-infectious …

Engineered toll-like receptor nanoagonist binding to extracellular matrix elicits safe and robust antitumor immunity

L Yang, Y Lang, H Wu, K Xiang, Y Wang, M Yu, Y Liu… - ACS …, 2023 - ACS Publications
Cancer immunotherapy, such as the Toll-like receptor (TLR) agonist including CpG
oligodeoxynucleotide, has shown potency in clinical settings. However, it is still confronted …

Antigen-presenting, self-assembled protein nanobarrels as an adjuvant-free vaccine platform against influenza virus

S Kang, Y Kim, Y Shin, JJ Song, S Jon - ACS nano, 2021 - ACS Publications
Although naturally occurring, self-assembled protein nanoarchitectures have been utilized
as antigen-delivery carriers, and the inability of such carriers to elicit immunogenicity …

Bystander activation of irrelevant CD4+ T cells following antigen-specific vaccination occurs in the presence and absence of adjuvant

S van Aalst, IS Ludwig, R van der Zee, W van Eden… - PloS one, 2017 - journals.plos.org
Autoimmune and other chronic inflammatory diseases (AID) are prevalent diseases which
can severely impact the quality of life of those that suffer from the disease. In most cases, the …