Members of the CCN family of matricellular proteins are crucial for embryonic development
and have important roles in inflammation, wound healing and injury repair in adulthood …

Connective tissue growth factor (CTGF), a multifunctional protein of the CCN family,
regulates cell proliferation, differentiation, adhesion, and a variety of other biological …

Association studies of over 1 million SNPs capturing most of the human genome common
variation became possible thanks to the information provided by the HapMap International …

Systemic sclerosis (SSc) is a complex systemic disease characterised by fibrosis of the skin
and internal organs, vasculopathy, and activation of the immune system. The complex …

Background: Connective tissue growth factor (CTGF) has been identified as a key factor in
the pathogenesis of diseases with significant fibrosis-related complications such as …

Systemic sclerosis (SSc) is a fibrotic and autoimmune disease characterized clinically by
skin and internal organ fibrosis and vascular damage, and serologically by the presence of …

Systemic sclerosis is an autoimmune rheumatic disease characterised by fibrosis,
vasculopathy and inflammation. The exact aetiology of SSc remains unknown but evidences …

Systemic sclerosis (SS c) is a complex autoimmune connective tissue disease combining
inflammatory, vasculopathic and fibrotic manifestations. Skin features, which give their name …

Pathogenic processes that underlie the development and progression of systemic sclerosis
(SSc) are being defined in preclinical, clinical and genetic studies. Important evidence of …

Pseudoexfoliation syndrome (PEX) may lead to the development of pseudoexfoliative
glaucoma (PEG), a potential cause of irreversible blindness, if left untreated. This type of …