Significance: The precise role and impact of reactive oxygen species (ROS) in stem cells,
which are essential for lifelong tissue homeostasis and regeneration, remain of significant …

Various stem cells gradually turned to be critical players in tissue engineering and
regenerative medicine therapies. Current evidence has demonstrated that in addition to …

Dedicated stem cells ensure postnatal growth, repair and homeostasis of skeletal muscle.
Following injury, muscle stem cells (MuSCs) exit from quiescence and divide to reconstitute …

New therapeutic approaches are needed to treat leukemia effectively. Dietary restriction
regimens, including fasting, have been considered for the prevention and treatment of …

Hematopoietic stem cells (HSC) are primarily dormant but have the potential to become
highly active on demand to reconstitute blood. This requires a swift metabolic switch from …

Mitochondria perform diverse functions in the cell and their roles during processes such as
cell survival, differentiation, and migration are increasingly being appreciated. Mitochondrial …

Quiescence maintenance is an important property of hematopoietic stem cells (HSCs),
whereas the regulatory factors and underlying mechanisms involved in HSC quiescence …

Hematopoietic stem cells (HSCs) reside at the top of the hematopoietic hierarchy, exhibiting
a unique capacity to self-renew and differentiate into all blood cells throughout the lifetime …

Alternative polyadenylation (APA) has been discovered to play regulatory roles in the
development of many cancer cells through preferential addition of a poly (A) tail at specific …

Hematopoietic stem cells (HSCs) are known to reside in a bone marrow (BM) niche, which is
associated with relatively higher calcium content. HSCs sense and respond to calcium …