Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Endomembrane trafficking is essential for all eukaryotic cells. The best-characterized
membrane trafficking organelles include the endoplasmic reticulum (ER), Golgi apparatus …

Coronavirus M proteins represent the major protein component of the viral envelope. They
play an essential role during viral assembly by interacting with all of the other structural …

Highlights•The plant vacuole is the major site for sugar storage.•The activities of vacuolar
sugar porters determine plant yield and stress tolerance.•The vacuole is energized by two …

As a result of a whole-exome sequencing study, we report three mutant alleles in SEC24D, a
gene encoding a component of the COPII complex involved in protein export from the ER …

Secretion and assembly of collagen are fundamental to the function of the extracellular
matrix. Defects in the assembly of a collagen matrix lead to pathologies including fibrosis …

In mammalian cells, cargo‐laden secretory vesicles leave the endoplasmic reticulum (ER)
en route to ER‐Golgi intermediate compartments (ERGIC) in a manner dependent on the …

The conserved coat protein complex II (COPII) mediates the initial steps of secretory protein
trafficking by assembling onto subdomains of the endoplasmic reticulum (ER) in two layers …

The sorting and distribution to different final destinations of roughly a third of the membrane
and secreted proteins occurs at the level of the trans‐Golgi network (TGN). This TGN …

Metazoans require efficient and ordered secretion of extracellular matrix (ECM) to
coordinate cell and tissue function. Many ECM proteins are atypically large and their …