SOX9 in organogenesis: shared and unique transcriptional functions

Z Ming, B Vining, S Bagheri-Fam, V Harley - Cellular and Molecular Life …, 2022 - Springer
The transcription factor SOX9 is essential for the development of multiple organs including
bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human …

Master-key regulators of sex determination in fish and other vertebrates—A review

AY Curzon, A Shirak, M Ron, E Seroussi - International Journal of …, 2023 - mdpi.com
In vertebrates, mainly single genes with an allele ratio of 1: 1 trigger sex-determination (SD),
leading to initial equal sex-ratios. Such genes are designated master-key regulators (MKRs) …

Turnover of mammal sex chromosomes in the Sry-deficient Amami spiny rat is due to male-specific upregulation of Sox9

M Terao, Y Ogawa, S Takada… - Proceedings of the …, 2022 - National Acad Sciences
Mammalian sex chromosomes are highly conserved, and sex is determined by SRY on the
Y chromosome. Two exceptional rodent groups in which some species lack a Y …

Overview of avian sex reversal

X Zhang, J Li, S Chen, N Yang, J Zheng - International Journal of …, 2023 - mdpi.com
Sex determination and differentiation are processes by which a bipotential gonad adopts
either a testicular or ovarian cell fate, and secondary sexual characteristics adopt either …

SOX9 及其增强子在哺乳动物性别决定中的研究进展

杨敏, 林思远, 杨长淇, 陈瑶生, 何祖勇 - 遗传, 2024 - chinagene.cn
性别决定指的是胚胎发育早期, 在转录因子的精确调控下, 具有双重分化潜能的性腺向睾丸(雄性)
或卵巢(雌性) 方向转变的过程. SOX9 (SRY-box transcription factor 9) 是哺乳动物发育过程中 …

Identification of a New Enhancer That Promotes Sox9 Expression by a Comparative Analysis of Mouse and Sry-Deficient Amami Spiny Rat

Y Hirata, S Mizushima, S Mitsukawa, M Kon… - … and Genome Research, 2023 - karger.com
Introduction: Testis differentiation is initiated by the SRY gene on the Y chromosome in
mammalian species. However, the Amami spiny rat, Tokudaia osimensis, lacks both the Y …