[HTML][HTML] Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer's disease: A systematic review
D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing research reviews, 2021 - Elsevier
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …
affecting around 46 million people worldwide but few treatments are currently available. The …
Alzheimer's pathogenic mechanisms and underlying sex difference
AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …
women than men: almost two-thirds of patients with AD are women. One prevailing view is …
Sex differences in genetic architecture in the UK Biobank
Males and females present differences in complex traits and in the risk of a wide array of
diseases. Genotype by sex (GxS) interactions are thought to account for some of these …
diseases. Genotype by sex (GxS) interactions are thought to account for some of these …
An App knock-in rat model for Alzheimer's disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments
A major obstacle in Alzheimer's disease (AD) research is the lack of predictive and
translatable animal models that reflect disease progression and drug efficacy. Transgenic …
translatable animal models that reflect disease progression and drug efficacy. Transgenic …
Neurodegenerative disease: roles for sex, hormones, and oxidative stress
N Sumien, JT Cunningham, DL Davis… - …, 2021 - academic.oup.com
Neurodegenerative diseases cause severe impairments in cognitive and motor function.
With an increasing aging population and the onset of these diseases between 50 and 70 …
With an increasing aging population and the onset of these diseases between 50 and 70 …
Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease
The pathogenesis of Alzheimer's disease (AD) depends on environmental and heritable
factors, with its molecular etiology still unclear. Here we present a spatial transcriptomic (ST) …
factors, with its molecular etiology still unclear. Here we present a spatial transcriptomic (ST) …
Protective genes and pathways in Alzheimer's disease: moving towards precision interventions
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that is characterized
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …
[HTML][HTML] Genetic architecture of Alzheimer's disease
Advances in genetic and genomic technologies over the last thirty years have greatly
enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD) …
enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD) …
Genetic variants and functional pathways associated with resilience to Alzheimer's disease
Approximately 30% of older adults exhibit the neuropathological features of Alzheimer's
disease without signs of cognitive impairment. Yet, little is known about the genetic factors …
disease without signs of cognitive impairment. Yet, little is known about the genetic factors …
Auditory sensory deprivation induced by noise exposure exacerbates cognitive decline in a mouse model of Alzheimer's disease
Although association between hearing impairment and dementia has been widely
documented by epidemiological studies, the role of auditory sensory deprivation in cognitive …
documented by epidemiological studies, the role of auditory sensory deprivation in cognitive …