High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …

For> 50 years, it has been recognized that immunity contributes to hypertension. Recent
data have defined an important role of T cells and various T cell–derived cytokines in …

Diabetes mellitus is known to trigger retinopathy, neuropathy and nephropathy. Diabetic
nephropathy, a long-term major microvascular complication of uncontrolled hyperglycemia …

Ample genetic and physiological evidence establishes that renal salt handling is a critical
regulator of blood pressure. Studies also establish a role for the immune system, T-cell …

Endothelial dysfunction is a characteristic feature during the renal damage induced by mild
hyperuricemia. The mechanism by which uric acid reduces the bioavailability of intrarenal …

Immune mechanisms have been recognized to have a role in the pathogenesis of
hypertension, vascular disease and kidney damage in humans and animals for many …

The renal renin–angiotensin system plays a major role in determining the rate of chronic
renal disease progression. Treatment with activators of the vitamin D receptor retards the …

Salt-sensitivity of blood pressure is an independent risk factor for cardiovascular disease
and affects approximately half of the hypertensive population. While the precise …

Hypertension and renal damage in Dahl SS rats are associated with increased infiltrating
immune cells in the kidney. To examine the role of infiltrating immune cells in this disease …

Hypertension is a common disorder with uncertain etiology. In the last several years, it has
become evident that components of both the innate and adaptive immune system play an …