Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary human and financial burdens. Studies of …

Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

Microglia-mediated synaptic loss contributes to the development of cognitive impairments in
Alzheimer's disease (AD). However, the basis for this immune-mediated attack on synapses …

Soluble amyloid-β oligomers (Aβo) trigger Alzheimer's disease (AD) pathophysiology and
bind with high affinity to cellular prion protein (PrP C). At the postsynaptic density (PSD) …

The misfolding of the cellular prion protein (PrP C) causes fatal neurodegenerative
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …

Amyloid-beta (Aβ) oligomers are thought to trigger Alzheimer's disease pathophysiology.
Cellular prion protein (PrPC) selectively binds oligomeric Aβ and can mediate Alzheimer's …

Neurodegenerative diseases are an enormous public health problem, affecting tens of
millions of people worldwide. Nearly all of these diseases are characterized by …

Several different receptor proteins have been identified that bind monomeric, oligomeric, or
fibrillar forms of amyloid-β (Aβ)." Good" receptors internalize Aβ or promote its transcytosis …

The prion protein, PrPC, is a small, cell-surface glycoprotein notable primarily for its critical
role in pathogenesis of the neurodegenerative disorders known as prion diseases. A …

There are a group of diseases associated with protein misfolding and accumulation into
amyloid fibers. Many of these diseases have a major impact on human health, in particular …