Cancer is a severe health problem that continues to be a leading cause of death worldwide.
Increasing knowledge of the molecular mechanisms underlying cancer progression has led …

Human papillomavirus (HPV)-induced cervical cancer is a major health issue among
women from the poorly/under-developed sectors of the world. It accounts for a high-mortality …

Plants are a rich source of new antiviral, pharmacologically active agents. The naturally
occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of …

Isoquinoline alkaloids, an important class of N‐based heterocyclic compounds, have
attracted considerable attention from researchers worldwide since the early 19th century …

Cellular ROS production participates in various cellular functions but its accumulation
decides the cell fate. Malignant cells have higher levels of ROS and active antioxidant …

Alkaloids are used in traditional medicine for the treatment of many diseases. These
compounds are synthesized in plants as secondary metabolites and have multiple effects on …

Background Berberis vulgaris is a well known plant with traditional herbal medical history.
The aims of this study was to bioscreen and compare the in vitro biological activity …

Cancer is the most commonly diagnosed type of disease and a major cause of death
worldwide. Despite advancement in various treatment modules, there has been little …

Berberine (BBR) has been confirmed to have multiple bioactivities in clinic, such as
cholesterol-lowering, anti-diabetes, cardiovascular protection and anti-inflammation …

Pyroptosis is a caspase-1 dependent programmed cell death, which is involved in the
pathologic process of several kinds of cancers. Loss of caspase-1 gene expression has …