RNA interference pathways in fungi: mechanisms and functions

SS Chang, Z Zhang, Y Liu - Annual review of microbiology, 2012 - annualreviews.org
RNA interference (RNAi) is a conserved eukaryotic gene regulatory mechanism that uses
small noncoding RNAs to mediate posttranscriptional/transcriptional gene silencing. The …

RNA interference in fungi: pathways, functions, and applications

Y Dang, Q Yang, Z Xue, Y Liu - Eukaryotic cell, 2011 - Am Soc Microbiol
Small RNA molecules of about 20 to 30 nucleotides function in gene regulation and
genomic defense via conserved eukaryotic RNA interference (RNAi)-related pathways. The …

Non-optimal codon usage affects expression, structure and function of clock protein FRQ

M Zhou, J Guo, J Cha, M Chae, S Chen, JM Barral… - Nature, 2013 - nature.com
Codon-usage bias has been observed in almost all genomes and is thought to result from
selection for efficient and accurate translation of highly expressed genes,,. Codon usage is …

Diverse pathways generate microRNA-like RNAs and Dicer-independent small interfering RNAs in fungi

HC Lee, L Li, W Gu, Z Xue, SK Crosthwaite… - Molecular cell, 2010 - cell.com
A variety of small RNAs, including the Dicer-dependent miRNAs and the Dicer-independent
Piwi-interacting RNAs, associate with Argonaute family proteins to regulate gene expression …

qiRNA is a new type of small interfering RNA induced by DNA damage

HC Lee, SS Chang, S Choudhary, AP Aalto, M Maiti… - Nature, 2009 - nature.com
RNA interference pathways use small RNAs to mediate gene silencing in eukaryotes. In
addition to small interfering RNAs (siRNAs) and microRNAs, several types of endogenously …

The evolutionary significance of RNAi in the fungal kingdom

C Lax, G Tahiri, JA Patiño-Medina… - International Journal of …, 2020 - mdpi.com
RNA interference (RNAi) was discovered at the end of last millennium, changing the way
scientists understood regulation of gene expression. Within the following two decades, a …

A single Argonaute gene is required for induction of RNA silencing antiviral defense and promotes viral RNA recombination

Q Sun, GH Choi, DL Nuss - Proceedings of the National …, 2009 - National Acad Sciences
Dicer gene dcl2, required for the RNA silencing antiviral defense response in the chestnut
blight fungus Cryphonectria parasitica, is inducible upon mycovirus infection and promotes …

Mycoviruses, RNA silencing, and viral RNA recombination

DL Nuss - Advances in virus research, 2011 - Elsevier
In contrast to viruses of plants and animals, viruses of fungi, mycoviruses, uniformly lack an
extracellular phase to their replication cycle. The persistent, intracellular nature of the …

Condensate cooperativity underlies transgenerational gene silencing

Z Du, K Shi, JS Brown, T He, WS Wu, Y Zhang, HC Lee… - Cell reports, 2023 - cell.com
Biomolecular condensates have been shown to interact in vivo, yet it is unclear whether
these interactions are functionally meaningful. Here, we demonstrate that cooperativity …

Discerning the prospects of miRNAs as a multi-target therapeutic and diagnostic for alzheimer's disease

D Bhatnagar, S Ladhe, D Kumar - Molecular Neurobiology, 2023 - Springer
Although over the last few decades, numerous attempts have been made to halt Alzheimer's
disease (AD) progression and mitigate its symptoms, only a few have been proven …