Dynamics and specificities of T cells in cancer immunotherapy
G Oliveira, CJ Wu - Nature Reviews Cancer, 2023 - nature.com
Recent advances in cancer immunotherapy—ranging from immune-checkpoint blockade
therapy to adoptive cellular therapy and vaccines—have revolutionized cancer treatment …
therapy to adoptive cellular therapy and vaccines—have revolutionized cancer treatment …
A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction
Human leukocyte antigen class I (HLA-I) molecules are encoded by major histocompatibility
complex (MHC) class I loci in humans. The binding and interaction between HLA-I …
complex (MHC) class I loci in humans. The binding and interaction between HLA-I …
A transformer-based model to predict peptide–HLA class I binding and optimize mutated peptides for vaccine design
Human leukocyte antigen (HLA) can recognize and bind foreign peptides to present them to
specialized immune cells, then initiate an immune response. Computational prediction of the …
specialized immune cells, then initiate an immune response. Computational prediction of the …
[HTML][HTML] Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction
The accurate selection of neoantigens that bind to class I human leukocyte antigen (HLA)
and are recognized by autologous T cells is a crucial step in many cancer immunotherapy …
and are recognized by autologous T cells is a crucial step in many cancer immunotherapy …
[HTML][HTML] Engineered cell entry links receptor biology with single-cell genomics
Cells communicate with each other via receptor-ligand interactions. Here, we describe
lentiviral-mediated cell entry by engineered receptor-ligand interaction (ENTER) to display …
lentiviral-mediated cell entry by engineered receptor-ligand interaction (ENTER) to display …
Predicting antigen presentation—what could we learn from a million peptides?
D Gfeller, M Bassani-Sternberg - Frontiers in immunology, 2018 - frontiersin.org
Antigen presentation lies at the heart of immune recognition of infected or malignant cells.
For this reason, important efforts have been made to predict which peptides are more likely …
For this reason, important efforts have been made to predict which peptides are more likely …
The function and dysfunction of memory CD8+ T cells in tumor immunity
JL Reading, F Gálvez‐Cancino… - Immunological …, 2018 - Wiley Online Library
The generation and maintenance of CD 8+ T cell memory is crucial to long‐term host
survival, yet the basic tenets of CD 8+ T cell immunity are still being established. Recent …
survival, yet the basic tenets of CD 8+ T cell immunity are still being established. Recent …
T cell antigen discovery via signaling and antigen-presenting bifunctional receptors
CD8+ T cells recognize and eliminate tumors in an antigen-specific manner. Despite
progress in characterizing the antitumor T cell repertoire and function, the identification of …
progress in characterizing the antitumor T cell repertoire and function, the identification of …
Nanoscale organization of two-dimensional multimeric pMHC reagents with DNA origami for CD8+ T cell detection
Y Sun, L Yan, J Sun, M Xiao, W Lai, G Song… - Nature …, 2022 - nature.com
Peptide-MHC (pMHC) multimers have excelled in the detection of antigen-specific T cells
and have allowed phenotypic analysis using other reagents, but their use for detection of …
and have allowed phenotypic analysis using other reagents, but their use for detection of …
The quest for the best: how TCR affinity, avidity, and functional avidity affect TCR-engineered T-cell antitumor responses
Over the past decades, adoptive transfer of T cells has revolutionized cancer
immunotherapy. In particular, T-cell receptor (TCR) engineering of T cells has marked …
immunotherapy. In particular, T-cell receptor (TCR) engineering of T cells has marked …