Emerging therapeutic potential of SIRT6 modulators
Sirtuin 6 (SIRT6) is an NAD+-dependent protein deacylase and mono-ADP-
ribosyltransferase of the sirtuin family with a wide substrate specificity. In vitro and in vivo …
ribosyltransferase of the sirtuin family with a wide substrate specificity. In vitro and in vivo …
Activation and inhibition of sirtuins: From bench to bedside
F Fiorentino, E Fabbrizi, A Mai… - Medicinal Research …, 2024 - Wiley Online Library
The sirtuin family comprises seven NAD+‐dependent enzymes which catalyze protein lysine
deacylation and mono ADP‐ribosylation. Sirtuins act as central regulators of genomic …
deacylation and mono ADP‐ribosylation. Sirtuins act as central regulators of genomic …
Cryo-EM structure of the human Sirtuin 6–nucleosome complex
Sirtuin 6 (SIRT6) is a multifaceted protein deacetylase/deacylase and a major target for
small-molecule modulators of longevity and cancer. In the context of chromatin, SIRT6 …
small-molecule modulators of longevity and cancer. In the context of chromatin, SIRT6 …
[HTML][HTML] The role of structural biology in the design of sirtuin activators
Sirtuins are NAD+-dependent protein lysine deacylases and mono-ADP-ribosylases whose
activity regulates different pathways, including DNA damage repair, cell survival and …
activity regulates different pathways, including DNA damage repair, cell survival and …
Sirtuin modulators: past, present, and future perspectives
F Fiorentino, N Mautone, M Menna… - Future Medicinal …, 2022 - Taylor & Francis
Sirtuins are NAD+-dependent protein lysine deacylase and mono-ADP ribosylases present
in both prokaryotes and eukaryotes. The sirtuin family comprises seven isoforms in …
in both prokaryotes and eukaryotes. The sirtuin family comprises seven isoforms in …
Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide‐Activated Sirtuin 7
JE Bolding, AL Nielsen, I Jensen… - Angewandte Chemie …, 2023 - Wiley Online Library
The sirtuins are NAD+‐dependent lysine deacylases, comprising seven isoforms (SIRT1–7)
in humans, which are involved in the regulation of a plethora of biological processes …
in humans, which are involved in the regulation of a plethora of biological processes …
Inhibition of Sirtuin Deacylase Activity by Peroxynitrite
K Bohl, SL Wynia-Smith, RA Jones Lipinski… - Biochemistry, 2024 - ACS Publications
Sirtuins are a class of enzymes that deacylate protein lysine residues using NAD+ as a
cosubstrate. Sirtuin deacylase activity has been historically regarded as protective; loss of …
cosubstrate. Sirtuin deacylase activity has been historically regarded as protective; loss of …
长寿蛋白SIRT6 在衰老和代谢中作用的研究进展
刘永慧， 唐莉， 梁泰刚， 张健… - 上海交通大学学报(医学版), 2024 - xuebao.shsmu.edu.cn
SIRT6 是组蛋白去乙酰化酶第三家族长寿蛋白中的一员, 具备依赖于烟酰胺腺嘌呤二核苷酸的脱
酰基酶活性和单ADP 核糖基转移酶活性. SIRT6 主要位于细胞核内, 可通过核心调控基因组稳定 …
酰基酶活性和单ADP 核糖基转移酶活性. SIRT6 主要位于细胞核内, 可通过核心调控基因组稳定 …
Fluorogenic Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide Activated SIRT7
JE Bolding, AL Nielsen, I Jensen, LA Ryberg… - bioRxiv, 2023 - biorxiv.org
The sirtuins are NAD+-dependent lysine deacylases, comprising seven isoforms (SIRT1–7)
in humans, which are involved in the regulation of a plethora of biology, including gene …
in humans, which are involved in the regulation of a plethora of biology, including gene …
Revealing chromatin-specific functions of histone deacylases
C Moreno-Yruela, B Fierz - Biochemical Society Transactions, 2024 - portlandpress.com
Histone deacylases are erasers of N ε-acyl-lysine post-translational modifications and have
been targeted for decades for the treatment of cancer, neurodegeneration and other …
been targeted for decades for the treatment of cancer, neurodegeneration and other …