The brain is a highly energy-demanding organ and requires bioenergetic adaptability to
balance normal activity with pathophysiological fuelling of spontaneous recurrent seizures …

The epilepsies are a group of complex neurological disorders characterised by recurrent
seizures. Approximately 30% of patients fail to respond to anti-seizure medications, despite …

Cerebral arachnoid cysts (ACs) are one of the most common and poorly understood types of
developmental brain lesion. To begin to elucidate AC pathogenesis, we performed an …

Zingiber officinale is one of the most frequently used medicinal herbs in Asia. Using rodent
seizure models, it was previously shown that Zingiber officinale hydroethanolic extract exerts …

Genetic epilepsy occurs as a result of mutations in either a single gene or an interplay of
different genes. These mutations have been detected in ion channel and non-ion channel …

A few published clinical studies have evaluated the association between gut microbiota in
intractable epilepsy, but with inconsistent results. We hypothesized that the factors …

Overcoming refractory epilepsy's resistance to the combination of antiepileptic drugs (AED),
mitigating side effects, and preventing sudden unexpected death in epilepsy are critical …

Prevention of epilepsy and its progression remains the most urgent need for epilepsy
research and therapy development. Novel conceptual advances are required to …

Managing epilepsy in people with an intellectual disability remains a therapeutic challenge
and must take into account additional issues such as diagnostic difficulties and frequent …

Seizure is a neurological disorder including hippocampal oxidative and inflammatory stress,
and glutamate toxicity. Thus, any agent (s) that mitigate (s) these events in hippocampus …