The defining trait of obligate anaerobes is that oxygen blocks their growth, yet the underlying
mechanisms are unclear. A popular hypothesis was that these microorganisms failed to …

Under anaerobic conditions and in the absence of alternative electron acceptors
Escherichia coli converts sugars to a mixture of products by fermentation. The major soluble …

We report in this paper that highly purified Escherichia coli dihydroxy-acid dehydratase,
fumarase A, fumarase B, and mammalian aconitase are inactivated by O2-with second order …

Biochemical network reconstructions have become popular tools in systems biology.
Metabolicnetwork reconstructions are biochemically, genetically, and genomically (BiGG) …

Ancient microbes invented biochemical mechanisms and assembled core metabolic
pathways on an anoxic Earth. Molecular oxygen appeared far later, forcing microbes to …

Anaplerosis is an essential feature of metabolism that allows the continuous operation of
natural metabolic networks, such as the citric acid cycle, by constantly replenishing drained …

This study characterizes mitochondria isolated from livers of Sod2−/+ and Sod2+/+ mice. A
50% decrease in manganese superoxide dismutase (MnSOD) activity was observed in …

D. Max Roundhillreceived his BA degree from Oxford University and his Ph D degree from
Imperial College, London with Geoffroy Wilkinson. After postdoctoral work at Tulane, he …

New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria
parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both …

Fumaric, l‐malic and citric acids are intermediates of the oxidative tricarboxylic acid (TCA)
cycle which in eukaryotes is localized in mitochondria. These organic acids are synthesized …