Molecular mechanisms of adipogenesis: the anti-adipogenic role of AMP-activated protein kinase

B Ahmad, CJ Serpell, IL Fong… - Frontiers in molecular …, 2020 - frontiersin.org
Obesity is now a widespread disorder, and its prevalence has become a critical concern
worldwide, due to its association with common co-morbidities like cancer, cardiovascular …

Toward a consensus view of mammalian adipocyte stem and progenitor cell heterogeneity

R Ferrero, P Rainer, B Deplancke - Trends in cell biology, 2020 - cell.com
White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only
serves as an energy reservoir, but also actively participates in metabolic homeostasis …

A large multiethnic genome-wide association study of adult body mass index identifies novel loci

TJ Hoffmann, H Choquet, J Yin, Y Banda, MN Kvale… - Genetics, 2018 - academic.oup.com
Body mass index (BMI), a proxy measure for obesity, is determined by both environmental
(including ethnicity, age, and sex) and genetic factors, with> 400 BMI-associated loci …

Transcriptional control of brown and beige fat development and function

SN Shapira, P Seale - Obesity, 2019 - Wiley Online Library
Adipose tissue, once viewed as an inert organ of energy storage, is now appreciated to be a
central node for the dynamic regulation of systemic metabolism. There are three general …

The complex pathophysiology of bone fragility in obesity and type 2 diabetes mellitus: therapeutic targets to promote osteogenesis

S Bathina, R Armamento-Villareal - Frontiers in endocrinology, 2023 - frontiersin.org
Fractures associated with Type2 diabetes (T2DM) are major public health concerns in an
increasingly obese and aging population. Patients with obesity or T2DM have normal or …

Brown and beige fat: from molecules to physiology and pathophysiology

S Carobbio, AC Guénantin, I Samuelson… - … et Biophysica Acta (BBA …, 2019 - Elsevier
The adipose organ portrays adipocytes of diverse tones: white, brown and beige, each type
with distinct functions. Adipocytes orchestrate their adaptation and expansion to provide …

[HTML][HTML] Role of bile acid receptor FXR in development and function of brown adipose tissue

J Yang, HD de Vries, A Mayeuf-Louchart… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Bile acids act as signalling molecules that contribute to maintenance of energy homeostasis
in mice and humans. Activation of G-protein-coupled bile acid receptor TGR5 induces …

Magnetic fields modulate metabolism and gut microbiome in correlation with Pgc‐1α expression: Follow‐up to an in vitro magnetic mitohormetic study

YK Tai, C Ng, K Purnamawati, JLY Yap… - The FASEB …, 2020 - Wiley Online Library
Exercise modulates metabolism and the gut microbiome. Brief exposure to low mT‐range
pulsing electromagnetic fields (PEMFs) was previously shown to accentuate in vitro …

The Developmental Implications of Muscle-Targeted Magnetic Mitohormesis: A Human Health and Longevity Perspective

A Franco-Obregón, YK Tai, KY Wu, JN Iversen… - Bioengineering, 2023 - mdpi.com
Muscle function reflects muscular mitochondrial status, which, in turn, is an adaptive
response to physical activity, representing improvements in energy production for de novo …

LncRNA Ctcflos orchestrates transcription and alternative splicing in thermogenic adipogenesis

A Bast‐Habersbrunner, C Kiefer, P Weber… - EMBO …, 2021 - embopress.org
The recruitment of thermogenic brite adipocytes within white adipose tissue attenuates
obesity and metabolic comorbidities, arousing interest in understanding the underlying …