▪ Abstract Eleven distinct isoforms of phosphoinositide-specific phospholipase C (PLC),
which are grouped into four subfamilies (β, γ, δ, and∍), have been identified in mammals …

Phosphatidic acid (PA) has emerged as a new class of lipid mediators involved in diverse
cellular functions in plants, animals, and microorganisms. Considerable progress has been …

▪ Abstract We review the physical properties of phosphatidylinositol 4, 5-bisphosphate (PIP2)
that determine both its specific interactions with protein domains of known structure and its …

There are numerous studies that suggest multiple links between the cellular
phosphoinositide system and cancer. As key roles in cancer have been established for PI3K …

The actin cytoskeleton is an essential scaffold for integrating membrane and intracellular
functions. It is very dynamic and is remodeled in response to a variety of signals. Growth …

Myo-inositol is a versatile compound that generates diversified derivatives upon
phosphorylation by lipid-dependent and-independent pathways. Phosphatidylinositols form …

Phosphoinositide-3 kinases (PI3Ks) are a family of evolutionary conserved lipid kinases that
mediate many cellular responses in both physiologic and pathophysiologic states. Class I …

Membrane phosphoinositides control a variety of cellular processes through the recruitment
and/or regulation of cytosolic proteins,,,. One mechanism ensuring spatial specificity in …

The ability of cells to form cell contacts, adhere to the extracellular matrix, change
morphology, and migrate is essential for development, wound healing, metastasis, cell …

Topoisomerase 11 is an essential enzyme that plays a role in virtually every cellular DNA
process. This enzyme interconverts different topological forms of DNA by passing one …