Tuberculosis is a significant health problem without an effective vaccine to combat it. A
thorough understanding of the immune response and correlates of protection is needed to …

Antigen-specific, MHC-restricted αβ T cells are necessary for protective immunity against
Mycobacterium tuberculosis, but the ability to broadly study these responses has been …

Tuberculosis (TB) is reported as one of the most prevailing life-threatening health problems,
affecting almost one third of the population globally. It is one of a major reason of death with …

Given the encouraging clinical results of both candidate subunit vaccines and revaccination
with Bacillus Calmette-Guérin (BCG) against tuberculosis (TB), there is support for …

Heterogeneity in human immune responses is difficult to model in standard laboratory mice.
To understand how host variation affects Bacillus Calmette Guerin–induced (BCG-induced) …

Tuberculosis (TB), also known as the “White Plague”, is caused by Mycobacterium
tuberculosis (Mtb). Before the COVID-19 epidemic, TB had the highest mortality rate of any …

Background BCG confers reduced, variable protection against pulmonary tuberculosis. A
more effective vaccine is needed. We evaluated the safety and immunogenicity of candidate …

Heterologous vaccine regimens could extend waning protection in the global population
immunized with Mycobacterium bovis Bacille Calmette-Guerin (BCG). We demonstrate that …

In most cases, Mycobacterium tuberculosis (Mtb) causes life-long chronic infections, which
poses unique challenges for the immune system. Most of the current tuberculosis (TB) …

The only licensed tuberculosis (TB) vaccine, Bacillus Calmette Guerin (BCG), fails to reliably
protect adolescents and adults from pulmonary TB, resulting in~ 1.6 million deaths annually …