Obese individuals frequently develop hypertension, which is for an important part
attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review …

The mineralocorticoid receptor (MR) was originally identified as a regulator of blood
pressure, able to modulate renal sodium handling in response to its principal ligand …

Ventricular–arterial coupling (VAC) plays a major role in the physiology of cardiac and aortic
mechanics, as well as in the pathophysiology of cardiac disease. VAC assessment …

Over the past decade, several studies have shown that activity of extra-renal
mineralocorticoid receptors (MR) regulates vascular tone, adipogenesis, adipose tissue …

The mineralocorticoid receptor (MR) belongs to the steroid hormone receptor family and
classically functions as a ligand-dependent transcription factor. It is involved in water …

Recent advances support the idea that endothelial cell mineralocorticoid receptor is a
mediator of the switch from vascular health to disease in response to CRFs. Further …

Cardiovascular disease remains the leading cause of death for both men and women. The
observation that premenopausal women are protected from cardiovascular disease relative …

Impaired endothelial insulin signaling and consequent blunting of insulin-induced
vasodilation is a feature of type 2 diabetes (T2D) that contributes to vascular disease and …

We have recently demonstrated the antithrombotic effect of eplerenone on the arterial
thrombotic process in diabetic rats associated with suppression of coagulation and …

Mineralocorticoid receptor activation in endothelial and smooth muscle cells can promote
vascular disease by increasing oxidative stress, promoting inflammation, accelerating …