Gametes are highly specialized cell types produced by a complex differentiation process.
Production of viable oocytes requires a series of precise and coordinated molecular events …

The long-term survival of any multicellular species depends on the success of its germline in
producing high-quality gametes and maximizing survival of the offspring. Studies in …

Drosophila ovarian germline stem cells (GSCs) are a powerful model for stem cell research.
In this study, we use single‐cell RNA sequencing (scRNA‐seq), an RNAi screen and …

PIWI proteins play essential roles in germ cells and stem cell lineages. In Drosophila, Piwi is
required in somatic niche cells and germline stem cells (GSC s) to support GSC self …

Drosophila melanogaster Bag-of-marbles (Bam) promotes germline stem cell (GSC)
differentiation by repressing the expression of mRNAs encoding stem cell maintenance …

Stem cells in adult tissues are constantly exposed to genotoxic stress and also accumulate
DNA damage with age. However, it remains largely unknown how DNA damage affects both …

Maternal mRNAs synthesized during oogenesis initiate the development of future
generations. Some maternal mRNAs are either somatic or germline determinants and must …

Stem cells support tissue maintenance, but the mechanisms that coordinate the rate of stem
cell self-renewal with differentiation at a population level remain uncharacterized. We find …

During oogenesis, several developmental processes must be traversed to ensure effective
completion of gametogenesis including, stem cell maintenance and asymmetric division …

The development of cancer is a complex multistage process. Over the past few decades, the
model organism Drosophila melanogaster has been crucial in identifying cancer‐related …