Key pathological, including oncogenic, signaling pathways regulate the canonical functions
of metabolic enzymes that serve the cellular metabolic needs. Importantly, these signaling …

Cancer cells undergo metabolic reprogramming and switch to a 'glycolysis-
dominant'metabolic profile to promote their survival and meet their requirements for energy …

Obesity and overweight have increased at an alarming rate in the world during the last three
decades. Obesity is a crucial factor in the development of metabolic abnormalities, including …

Metabolic disturbance, particularly of glucose metabolism, is a hallmark of tumors such as
non-small cell lung cancer (NSCLC). Cancer cells tend to reprogram a majority of glucose …

In light of the numerous studies identifying post-transcriptional regulators on the surface of
the endoplasmic reticulum (ER), we asked whether there are factors that regulate …

Abstract The POU Class Homeobox 2 (POU2F2) is a member of POU transcription factors
family, which involves in cell immune response by regulating B cell proliferation and …

Metabolism is a fundamental cellular process that can become harmful for cells by leading to
DNA damage, for instance by an increase in oxidative stress or through the generation of …

DNA repair and metabolic pathways are vital to maintain cellular homeostasis in normal
human cells. Both of these pathways, however, undergo extensive changes during …

Abstract Aims/Introduction Tubulointerstitial fibrosis is a hallmark of diabetic nephropathy
and is associated with an epithelial‐to‐mesenchymal transition (EMT) program and aberrant …

Reprogramming energy production from mitochondrial respiration to glycolysis is now
considered a hallmark of cancer. When tumors grow beyond a certain size they give rise to …