The Myc oncoprotein as a therapeutic target for human cancer
M Vita, M Henriksson - Seminars in cancer biology, 2006 - Elsevier
Myc expression is deregulated in a wide range of human cancers and is often associated
with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that …
with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that …
The clinical implications of medulloblastoma subgroups
PA Northcott, A Korshunov, SM Pfister… - Nature reviews …, 2012 - nature.com
Medulloblastoma, the most common malignant paediatric brain tumour, is currently
diagnosed and stratified using a combination of clinical and demographic variables. Recent …
diagnosed and stratified using a combination of clinical and demographic variables. Recent …
Identification of human brain tumour initiating cells
The cancer stem cell (CSC) hypothesis suggests that neoplastic clones are maintained
exclusively by a rare fraction of cells with stem cell properties,. Although the existence of …
exclusively by a rare fraction of cells with stem cell properties,. Although the existence of …
Identification of a cancer stem cell in human brain tumors
Most current research on human brain tumors is focused on the molecular and cellular
analysis of the bulk tumor mass. However, there is overwhelming evidence in some …
analysis of the bulk tumor mass. However, there is overwhelming evidence in some …
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
Background Medulloblastoma is the most common malignant brain tumor in children.
Despite recent improvements in cure rates, prediction of disease outcome remains a major …
Despite recent improvements in cure rates, prediction of disease outcome remains a major …
Mutations in SUFU predispose to medulloblastoma
The sonic hedgehog (SHH) signaling pathway directs the embryonic development of diverse
organisms and is disrupted in a variety of malignancies. Pathway activation is triggered by …
organisms and is disrupted in a variety of malignancies. Pathway activation is triggered by …
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
PA Northcott, Y Nakahara, X Wu, L Feuk, DW Ellison… - Nature …, 2009 - nature.com
We used high-resolution SNP genotyping to identify regions of genomic gain and loss in the
genomes of 212 medulloblastomas, malignant pediatric brain tumors. We found focal …
genomes of 212 medulloblastomas, malignant pediatric brain tumors. We found focal …
The genomic landscape of retinoblastoma: a review
Retinoblastoma is a paediatric ocular tumour that continues to reveal much about the
genetic basis of cancer development. Study of genomic aberrations in retinoblastoma …
genetic basis of cancer development. Study of genomic aberrations in retinoblastoma …
Brain tumours: classification and genes
VP Collins - Journal of Neurology, Neurosurgery & Psychiatry, 2004 - jnnp.bmj.com
Most recent classifications of brain tumours build on the 1926 work of Bailey and Cushing. 2
This classification named tumours after the cell type in the developing embryo/fetus or adult …
This classification named tumours after the cell type in the developing embryo/fetus or adult …
Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma
F Mendrzyk, B Radlwimmer, S Joos… - Journal of clinical …, 2005 - ascopubs.org
Purpose Medulloblastoma is the most common malignant brain tumor in children. Despite
multimodal aggressive treatment, nearly half of the patients die as a result of this tumor …
multimodal aggressive treatment, nearly half of the patients die as a result of this tumor …