α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

Abstract α-Synuclein is an abundant neuronal protein which localizes predominantly to
presynaptic terminals, and is strongly linked genetically and pathologically to Parkinson's …

Parkinson's disease (PD) is usually diagnosed through motor symptoms that make the
patient incapable of carrying out daily activities; however, numerous non-motor symptoms …

Parkinson's disease (PD) is a common neurodegenerative disorder, characterized
pathologically by the presence of α‐synuclein (α‐syn)‐rich Lewy bodies. As clinical …

Idiopathic Parkinson's disease (iPD) is a movement disorder characterized by the
degeneration of dopaminergic neurons and aggregation of the protein α‐synuclein. Patients …

The aggregation, deposition, and dysfunction of alpha-synuclein (aSyn) are common events
in neurodegenerative disorders known as synucleinopathies. These include Parkinson's …

Over the last two decades, many experimental and clinical studies have provided solid
evidence that alpha-synuclein (α-syn), a small, natively unfolded protein, is closely related to …

Increased α-synuclein gene (SNCA) dosage due to locus multiplication causes autosomal
dominant Parkinson's disease (PD). Variation in SNCA expression may be critical in …

Parkinson's disease (PD) is neuropathologically characterized as an alpha‐
synucleinopathy. Alpha‐synuclein‐containing inclusions are stained as L ewy bodies and L …

Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …