Retinoic acid (RA) signaling plays an important role during heart development in
establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and …

Abstract The Human Genome Project marked a major milestone in the scientific community
as it unravelled the~ 3 billion bases that are central to crucial aspects of human life. Despite …

The number one cause of human fetal death are defects in heart development. Because the
human embryonic heart is inaccessible and the impacts of mutations, drugs, and …

Using four-dimensional whole-embryo light sheet imaging with improved and accessible
computational tools, we longitudinally reconstruct early murine cardiac development at …

The capacity of pluripotent stem cells both for self-renewal and to differentiate into any cell
type have made them a powerful tool for studying human disease. Protocols for efficient …

During human spermatogenesis, germ cells undergo dynamic changes in chromatin
organization/re-packaging and in transcriptomes. In order to better understand the …

The cardiac outflow tract (OFT) transiently links the ventricles to the aortic sac and forms the
arterial valves. Abnormalities in these valves, such as bicuspid aortic valve (BAV), are …

Proper development and function of the vertebrate heart is vital for embryonic and postnatal
life. Many congenital heart defects in humans are associated with disruption of genes that …

Metabolism is the fundamental process that sustains life. The heart, in particular, is an organ
of high energy demand, and its energy substrates have been studied for more than a …

This study was conducted to determine the dynamic Islet1 and Brn3 (POU4F) expression
pattern in the human fetal retina and human‐induced pluripotent stem cell‐(hiPSC‐) derived …