Melatonin is ubiquitous molecule with wide distribution in nature and is produced by many
living organisms. In human beings, pineal gland is the major site for melatonin production …

Melatonin modulates a wide range of physiological functions with pleiotropic effects on the
immune system. Despite the large number of reports implicating melatonin as an …

Melatonin is the major secretory product synthesized and secreted by the pineal gland and
shows both a wide distribution within phylogenetically distant organisms from bacteria to …

Melatonin affects a variety of physiological processes including circadian rhythms, cellular
redox status, and immune function. Importantly, melatonin significantly influences T‐cell …

There is growing evidence that preceding the diagnosis or classification of systemic lupus
erythematosus (SLE), patients undergo a preclinical phase of disease where markers of …

Melatonin is the major secretory product of the pineal gland during the night and has
multiple activities including the regulation of circadian and seasonal rhythms, and …

Melatonin is a methoxyindole synthesized within the pineal gland. The hormone is secreted
during the night and appears to play multiple roles within the human organism. The …

Autoimmune diseases are a broad spectrum of disorders involved in the imbalance of T-cell
subsets, in which interplay or interaction of Th1, Th17 and Tregs are most important …

Systemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease
characterised by multiple organ involvement and a large number of complications. SLE …

Melatonin is a neurohormone mainly produced by the pineal gland following a circadian
rhythm. It is characterized as a pleiotropic factor because it not only regulates the wake …