With rapidly increasing prevalence, diabetes has become one of the major causes of
mortality worldwide. According to the latest studies, genetic information makes substantial …

The co-occurrence of schizophrenia (SCZ) and type 2 diabetes mellitus (T2D) has been well
documented. This review article focuses on the hypothesis that the co-occurrence of SCZ …

In this sweeping exploration of the relatively recent obesity epidemic, Michael L. Power and
Jay Schulkin probe evolutionary biology, history, physiology, and medical science to …

Several studies have identified nearly 40 different type 2 diabetes susceptibility loci, mainly
in European populations, but few of them have been evaluated in the Mexican population …

The phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) pathway
plays pivotal roles in cell survival, growth, and proliferation downstream of growth factors. Its …

Small molecular weight GTPases (small G proteins) are essential in the transduction of
signals from different plasma membrane receptors. Due to their endogenous GTP …

Although a causative role for RhoA-Rho kinase has been recognized in the development of
human hypertension, the molecular mechanism (s) and the RhoA guanine exchange factor …

To systematically evaluate genetic susceptibility to type 2 diabetes (T2D) in “candidate”
regions on chromosomes 1q, 3q and 12q, we examined disease association by using a total …

Increasing evidence has accumulated to implicate overactivation of Rho protein as a
common component for the pathogenesis of several cardiovascular disorders including …

Adipose tissue is crucial for the maintenance of energy and metabolic homeostasis and its
deregulation can lead to obesity and type II diabetes (T2D). Using gene disruption in the …