Bioresponsive immunotherapeutic materials

J Han, T Sheng, Y Zhang, H Cheng, J Gao… - Advanced …, 2023 - Wiley Online Library
The human immune system is an interaction network of biological processes, and its
dysfunction is closely associated with a wide array of diseases, such as cancer, infectious …

Engineering Single-Atom Iron Nanozymes with Radiation-Enhanced Self-Cascade Catalysis and Self-Supplied H2O2 for Radio-enzymatic Therapy

X Zhu, J Wu, R Liu, H Xiang, W Zhang, Q Chang… - ACS …, 2022 - ACS Publications
Single-atom nanozymes (SAzymes), with individually isolated metal atom as active sites,
have shown tremendous potential as enzyme-based drugs for enzymatic therapy. However …

Nanotechnology‐enhanced radiotherapy and the abscopal effect: Current status and challenges of nanomaterial‐based radio‐immunotherapy

D Viswanath, J Park, R Misra, VJ Pizzuti… - Wiley …, 2024 - Wiley Online Library
Rare but consistent reports of abscopal remission in patients challenge the notion that
radiotherapy (RT) is a local treatment; radiation‐induced cancer cell death can trigger …

Biocompatible tantalum nanoparticles as radiosensitizers for enhancing therapy efficacy in primary tumor and metastatic sentinel lymph nodes

C Ji, M Zhao, C Wang, R Liu, S Zhu, X Dong, C Su… - ACS …, 2022 - ACS Publications
Metastasis of breast carcinoma is commonly realized through lymphatic circulation, which
seriously threatens the lives of breast cancer patients. Therefore, efficient therapy for both …

Piezoelectric materials for synergistic piezo-and radio-catalytic tumor therapy

Y Liao, D Wang, S Zhu, R Zhou, F Rahbarizadeh, Z Gu - Nano Today, 2022 - Elsevier
Radio-catalytic therapy (RCT) is emerging as a split-new sensitization modality for photon
radiotherapy. However, the outcome of RCT is greatly hurdled by the insufficient intracellular …

Construction of an endogenously activated catalytic DNA circuit for highly robust in vivo microRNA imaging

Y Shang, Y Chen, Q Wang, Y He, S He, S Yu, X Liu… - Nano Today, 2022 - Elsevier
Catalytic DNA circuit, a versatile synthetic molecular nanodevice, shows great potential for in
vivo bioimaging application, yet is distorted by its off-site signal leakage. The endogenously …

Catalytic MnWO4 Nanorods for Chemodynamic Therapy Synergized Radiotherapy of Triple Negative Breast Cancer

B Zhao, Z Ma, S Ding, Y Cao, J Du… - Advanced Functional …, 2023 - Wiley Online Library
Nanomedicine‐based synergy of chemodynamic therapy (CDT) and radiotherapy (RT)
modulated by tumor microenvironment enables rapid tumor ablation, which holds great …

Bi2–xMnxO3 Nanospheres Engaged Radiotherapy with Amplifying DNA Damage

B Chen, L Xiao, W Wang, L Xu, Y Jiang… - … Applied Materials & …, 2023 - ACS Publications
Radiotherapy efficacy was greatly limited by hypoxia and overexpression of glutathione
(GSH) in the tumor microenvironment (TME), which maintained the immunosuppressive …

Well-established immunotherapy with R837-loaded boron neutron capture-shocked tumor cells

K Chen, S Liu, L Lv, J Tong, J Chen, H Liang, Y Wang… - Nano Today, 2023 - Elsevier
Although boron neutron capture therapy (BNCT) has been regarded as a curative therapy
for aggressive tumors, the frequency of tumor recurrence and metastasis remains high …

Glutathione-responsive and-exhausting metal nanomedicines for robust synergistic cancer therapy

P Liu, L Hao, M Liu, S Hu - Frontiers in Bioengineering and …, 2023 - frontiersin.org
Due to their rapid and uncontrolled proliferation, cancer cells are characterized by
overexpression of glutathione (GSH), which impairs reactive oxygen species (ROS)-based …