G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery
M Zhang, T Chen, X Lu, X Lan, Z Chen… - Signal Transduction and …, 2024 - nature.com
G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …
an important class of drug targets, play a role in maintaining numerous physiological …
P2Y receptors in neuropathic pain
X Zhang, G Li - Pharmacology Biochemistry and Behavior, 2019 - Elsevier
This review summarizes and evaluates the relationship between neuropathic pain and P2Y
receptors from inception to 2019. Purinergic receptors have been well studied in recent …
receptors from inception to 2019. Purinergic receptors have been well studied in recent …
Nucleotide P2Y1 receptor agonists are in vitro and in vivo prodrugs of A1/A3 adenosine receptor agonists: implications for roles of P2Y1 and A1/A3 receptors in …
TE Liston, S Hinz, CE Müller, DM Holstein… - Purinergic …, 2020 - Springer
Rapid phosphoester hydrolysis of endogenous purine and pyrimidine nucleotides has
challenged the characterization of the role of P2 receptors in physiology and pathology …
challenged the characterization of the role of P2 receptors in physiology and pathology …
Dopamine induces inhibitory effects on the circular muscle contractility of mouse distal colon via D1-and D2-like receptors
M Auteri, MG Zizzo, A Amato, R Serio - Journal of physiology and …, 2016 - Springer
Dopamine (DA) acts as gut motility modulator, via D1-and D2-like receptors, but its effective
role is far from being clear. Since alterations of the dopaminergic system could lead to …
role is far from being clear. Since alterations of the dopaminergic system could lead to …
Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders
JJ DiCello, SE Carbone, A Saito… - American Journal …, 2022 - journals.physiology.org
Allosteric modulators (AMs) are molecules that can fine-tune signaling by G protein-coupled
receptors (GPCRs). Although they are a promising therapeutic approach for treating a range …
receptors (GPCRs). Although they are a promising therapeutic approach for treating a range …
P2Y1 receptor in the colonic submucosa of rats and its association with opioid‑induced constipation
Y Zhao, X Ren, F Li, B Jia, D Wang… - Experimental and …, 2022 - spandidos-publications.com
The aim of the present study was to explore the expression changes of P2Y purinergic
receptor 1 (P2Y1) in the distal colonic submucosa of opioid-induced constipation (OIC) rats …
receptor 1 (P2Y1) in the distal colonic submucosa of opioid-induced constipation (OIC) rats …
The asymmetric innervation of the circular and longitudinal muscle of the mouse colon differently modulates myogenic slow phasic contractions
S Traserra, S Villarte, C Traini, S Palacin… - …, 2020 - Wiley Online Library
Background Neuromuscular transmission has been extensively studied in the circular layer
of the mouse colon where a co‐transmission of purines acting on P2Y1 receptors and NO …
of the mouse colon where a co‐transmission of purines acting on P2Y1 receptors and NO …
Studies towards the development of a PET radiotracer for imaging of the P2Y1 receptors in the brain: synthesis, 18F-labeling and preliminary biological evaluation
RP Moldovan, B Wenzel, R Teodoro… - European Journal of …, 2019 - Elsevier
Purine nucleotides such as ATP and ADP are important extracellular signaling molecules in
almost all tissues activating various subtypes of purinoreceptors. In the brain, the P2Y 1 …
almost all tissues activating various subtypes of purinoreceptors. In the brain, the P2Y 1 …
P2Y1 purinergic receptor modulate axon initial segment initial development
W Zhang, A Bonadiman, M Ciorraga… - Frontiers in cellular …, 2019 - frontiersin.org
Morphological and functional polarization of neurons depends on the generation and
maintenance of the axon initial segment (AIS). This axonal domain maintains axonal …
maintenance of the axon initial segment (AIS). This axonal domain maintains axonal …
Diadenosine tetraphosphate activates P2Y1 receptors that cause smooth muscle relaxation in the mouse colon
A Paquola, N Mañé, MC Giron, M Jimenez - European Journal of …, 2019 - Elsevier
P2Y 1 receptors play an essential role in inhibitory neuromuscular transmission in the
gastrointestinal tract. The signalling pathway involves the opening of small conductance …
gastrointestinal tract. The signalling pathway involves the opening of small conductance …