Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …

Highlights•Glycosidases carry out many essential functions across all domains of
life.•Activity-based probes can interrogate complex biological samples for glycosidase …

Activity-based protein profiling (ABPP) has become an emerging chemical proteomic
approach to illustrate the interaction mechanisms between compounds and proteins. This …

Glucocerebrosidase (GBA) is a lysosomal β‐glucosidase‐degrading glucosylceramide. Its
deficiency causes Gaucher disease (GD), a common lysosomal storage disorder. Carrying a …

Plant polysaccharides represent a virtually unlimited feedstock for the generation of biofuels
and other commodities. However, the extraordinary recalcitrance of plant polysaccharides …

The combined inhibition of endoplasmic reticulum (ER) α-glucosidases I and II has been
shown to inhibit replication of a broad range of viruses that rely on ER protein quality control …

Aziridines are the saturated three-membered cyclic amines that constitute an important
group of synthetic intermediates. These could act as a precursor for diverse organic …

GBA2, the non-lysosomal β-glucosylceramidase, is an enzyme involved in glucosylceramide
metabolism. Pharmacological inhibition of GBA2 by N-alkyl iminosugars is well tolerated …

Aziridines (azacyclopropanes) constitute the well-known class of heterocyclic compounds.
The studies on synthesis and reactivity of aziridines have drawn tremendous interest of …

μ-glucosidases [GBA1 (glucocerebrosidase) and GBA2] are ubiquitous essential enzymes.
Lysosomal GBA1 and cytosol-facing GBA2 degrade glucosylceramide (GlcCer); GBA1 …