Currently, a new line of research on mitochondria-targeted anticancer drugs is actively
developing in the field of biomedicine and medicinal chemistry. The distinguishing features …

A series of new betulinic and ursolic acid conjugates with a lipophilic triphenylphosphonium
cation, meant to enhance the bioavailability and mitochondriotropic action of natural …

The biocompatible protein nanocarrier with homogeneous particle size is a promising
candidate material for the delivery of targeted drugs to tumors. Doxorubicin (DOX) is a …

Exploration of a green carrier to avoid potential systemic toxicity and the unclear metabolic
mechanism of traditional nanocarriers is of high importance for cancer therapy. Hence, we …

Activation of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is well documented
for a broad spectrum of human malignancies supporting their growth and progression …

Triterpene acids, namely, 20, 29-dihydrobetulinic acid (BA), ursolic acid (UA) and oleanolic
acid (OA) were converted into C-28-amino-functionalized triterpenoids 4–7, 8a, 15, 18 and …

Leishmaniasis is an important neglected tropical disease, affecting more than 12 million
people worldwide. The available treatments are not well tolerated and present diverse side …

Cancer cells' resistance to anticancer drugs represents a major clinical problem and the
most important failure of treatment. Combination chemotherapy is more effective than …

Tumor necrosis factor receptor-associated factor 6 (TRAF6), an (K63) E3-ligase, plays a role
in many biological processes and its activity is relevant in diffuse large B cell lymphoma …

Previous study revealed that elevated expression of RAB27B in tissues is correlated with
hepatocellular carcinoma (HCC) progression; however, the mechanisms involved in …